Immunohistochemistry of transforming growth factor .BETA.1 in acute liver injury.
نویسندگان
چکیده
منابع مشابه
Transforming Growth Factor-beta1 as Lung Injury Biomarker: a Review
Lung injury, induced by chemicals, radiotherapy or others agents is marked by enhancement in the expression of transforming growth factor beta1 (TGF-1) as a result of inflammation. TGF-1 appears to be the major profibrogenic cytokine which regulates the production and deposition of the major extracellular matrix molecules (ECM) and has been reported to be involved in a host of cellular respon...
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All three isoforms of transforming growth factors beta (TGF-betal, TGF-beta2, and TGF-beta3) are secreted as latent complexes and activated extracellularly, leading to the release of the mature cytokines from their noncovalently associated proregions, also known as latency-associated peptides (LAPs). The LAP region of TGF-beta1 was expressed in a baculovirus expression system and purified to ho...
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Transforming growth factor beta-1 (TGF-beta1) is a potent inhibitor of hepatocyte growth both in vivo and in vitro. In this study, we analyzed the effects of TGF-beta1 on both naturally occurring and diethylnitrosamine-induced hepatocarcinogenesis using single transgenic TGF-beta1 and double transgenic c-myc/TGF-beta1 mice in which the expression of both transgenes was targeted to the liver. He...
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The effect of cytokines on the expression of selenoprotein P (SeP) in the human liver cell line HepG2 was investigated. Treatment with interleukin-1beta, interferon-gamma, and tumor necrosis factor-alpha had no effect on SeP levels in culture media or on SeP mRNA expression. Conversely, Western analysis revealed a dose-dependent reduction of SeP content in culture medium after treatment with tr...
متن کاملMyofibroblasts and Transforming Growth Factor-Beta1 in Reactive Gingival Overgrowths
OBJECTIVES The purpose of this study was to evaluate the oral health-related quality of life of patients treated with implant-supported mandibular overdentures and to compare the attachment systems used. MATERIAL AND METHODS The presence of myofibroblasts as well as transforming growth factor-beta1 was examined in twenty cases of fibrous epulis and 22 ossifying fibrous epulis, using immunohis...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1992
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.33.839